Manipulation of the Glass Transition Properties of a High-Solid System Made of Acrylic Acid-N,N′-Methylenebisacrylamide Copolymer Grafted on Hydroxypropyl Methyl Cellulose

International Journal of Molecular Sciences

Taghrid Istivan¹  Felicity Whitehead¹  Stefan Kasapis¹  Nazim Nassar¹  Robert Shanks² 

[1] School of Science, RMIT University, Bundoora West Campus, Melbourne, VIC 3083, Australia;School of Science, RMIT University, City Campus, Melbourne, VIC 3001, Australia;

关键词: hydroxypropyl methyl cellulose;    acrylic acid;    N,N′-methylenebisacrylamide;    glass transition temperature;   

DOI  :  10.3390/ijms22052682

来源: DOAJ

【 摘 要 】

Crosslinking of hydroxypropyl methyl cellulose (HPMC) and acrylic acid (AAc) was carried out at various compositions to develop a high-solid matrix with variable glass transition properties. The matrix was synthesized by the copolymerisation of two monomers, AAc and N,N′-methylenebisacrylamide (MBA) and their grafting onto HMPC. Potassium persulfate (K₂S₂O₈) was used to initiate the free radical polymerization reaction and tetramethylethylenediamine (TEMED) to accelerate radical polymerisation. Structural properties of the network were investigated with Fourier transform infrared spectroscopy (FTIR), Xray diffraction (XRD), modulated differential scanning calorimetry (MDSC), small-deformation dynamic oscillation in-shear, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The results show the formation of a cohesive macromolecular entity that is highly amorphous. There is a considerable manipulation of the rheological and calorimetric glass transition temperatures as a function of the amount of added acrylic acid, which is followed upon heating by an extensive rubbery plateau. Complementary TGA work demonstrates that the initial composition of all the HPMC-AAc networks is maintained up to 200 °C, an outcome that bodes well for applications of targeted bioactive compound delivery.

【 授权许可】

Unknown