The protective role of Piper nigrum fruit extract in an ovalbumin-induced allergic rhinitis by targeting of NFκBp65 and STAT3 signalings

Biomedicine & Pharmacotherapy

Chun Hua Piao¹  So-young Lee²  Chang Ho Song²  Sun Young Jung³  Yanjing Fan³  Eunjin Hyeon³  Thi Van Nguyen³  Ok Hee Chai⁴  Hee Soon Shin⁴  Dae Woon Choi⁴  Thi Tho Bui⁵ 

[1] Environmental Science, University of Education, The University of Danang, Danang 59000, Viet Nam;Food Biotechnology Program, Korea University of Science and Technology, Daejeon 34113, Republic of Korea;Department of Anatomy, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea;Division of Nutrition and Metabolism Research, Korea Food Research Institute, Wanju-gun, Jeonbuk 55365, Republic of Korea;;Faculty of Biology &

关键词: Piper nigrum;    Allergic rhinitis;    Eosinophil;    STAT3;    NFκBp65;    Nasal epithelium;   

DOI  :  

来源: DOAJ

【 摘 要 】

Piper nigrum L. is commonly used as a traditional medicine and food in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of P. nigrum on allergic rhinitis (AR) has been unclear. In the present study, an OVA-induced AR mice model were established to investigate the anti-allergic, anti-inflammation properties of P. nigrum fruit extract (PNE). Oral administrations of PNE inhibited the allergic nasal symptoms including rubbing and sneezing in the early-phage of AR. In both NALF and nasal tissue, PNE suppressed the inflammatory cells accumulation, specifically with eosinophils in NALF. Additionally, PNE prevented the activation of STAT3 and NFκBp65 signaling in the cytoplasm which led to increasing the synthesis of the anti-inflammatory Th1 cytokines and suppressing the inflammatory Th2, Th17 cytokines. These obtained results suggest that PNE has the promising strategy for immunotherapy in allergic rhinitis disease.

【 授权许可】

Unknown