H2S as a Bridge Linking Inflammation, Oxidative Stress and Endothelial Biology: A Possible Defense in the Fight against SARS-CoV-2 Infection?

Biomedicines

Cristina Vassalle¹  Francesca Gorini²  Melania Gaggini²  Serena Del Turco²  Laura Sabatino² 

[1] Fondazione CNR-Regione Toscana G. Monasterio, 56124 Pisa, Italy;Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy;

关键词: endothelium;    hydrogen sulfide;    inflammation;    therapeutic target;    SARS-CoV-2;    COVID-19;   

DOI  :  10.3390/biomedicines9091107

来源: DOAJ

【 摘 要 】

The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. In recent years, within the complexity of the inflammatory scenario related to loss of vessel integrity, hydrogen sulfide (H₂S) has aroused great interest due to its importance in different signaling pathways at the endothelial level. In this review, we discuss the effects of H₂S, a molecule which has been reported to demonstrate anti-inflammatory activity, in addition to many other biological functions related to endothelium and sulfur-drugs as new possible therapeutic options in diseases involving vascular pathobiology, such as in SARS-CoV-2 infection.

【 授权许可】

Unknown