The Effect of Particulate Matter Exposure on the Inflammatory Airway Response of Street Runners and Sedentary People

Atmosphere

CatherineM. Katekaru¹  LucasG. Pagani¹  MatheusC. de Sá¹  JulianaM.B. Santos¹  Marcelo Rossi¹  AndreL.L. Bachi¹  Mauro Vaisberg¹  JonatasB. Amaral¹  Roberta Foster¹  LuizA. Luna Junior¹  DominiqueM.A. Bullens²  Anne-Charlotte Jonckheere²  FrancineM. Almeida³  RodolfoP. Vieira⁴ 

[1] ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo 04025-002, Brazil;KU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology research group, UZ Herestraat 49 box 811, 3000 Leuven, Belgium;Medicine School, São Paulo University, Av. Dr. Arnaldo, 455-Cerqueira César, Sao Paulo 01246-903, Brazil;Post-graduation Program in Science of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Av. Ana Costa, 95-Vila Mathias-Santos, Sao Paulo 11060-001, Brazil;

关键词: particulate matter;    airway;    cytokines;    runners;    sedentary individuals;    inflammation;   

DOI  :  10.3390/atmos11010043

来源: DOAJ

【 摘 要 】

Physical exercise promotes many health benefits. However, its effects are not well known in a polluted environment. Thus, this study aimed to compare upper airway inflammatory responses between street runners and sedentary individuals. Twenty-eight volunteers were recruited: runners (n = 14) and sedentary individuals (n = 14), who lived and worked in the same metropolitan area of São Paulo, Brazil. Particulate matter (PM) levels were monitored ten weeks before winter (low PM levels) and ten weeks after the beginning of winter (high PM levels) [PM₁₀ (p < 0.0001) and PM_2.5 (p < 0.0001)]. The cytokines (TNF-α, IL-6, IL-10, and IL-17A) levels in the nasal lavage and fractional exhaled nitric oxide (FeNO) were taken at the beginning of the winter (baseline) and ten weeks afterwards (after ten weeks of high PM exposure). IL-6 concentration increased in both runners (p = 0.037) and sedentary individuals (p = 0.027) after high PM exposure compared to the baseline. IL-10 concentration increased in sedentary individuals (p = 0.037) while IL-17A levels were increased in runners (p = 0.001) after high PM exposure compared to the baseline. FeNO levels decreased in runners (p = 0.025) after high PM exposure compared to the baseline. Outdoor endurance training acts as an inducer of a differentiated immune response in the upper airways of runners compared to individuals with a sedentary lifestyle from the same community after elevated PM exposure.

【 授权许可】

Unknown