In Situ Assembly of Nanomaterials and Molecules for the Signal Enhancement of Electrochemical Biosensors

Nanomaterials

Yong Chang¹  Yaliang Huang¹  Ning Xia¹  Zhifang Sun¹  Lin Liu¹ 

[1] College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China;

关键词: electrochemical biosensors;    self-assembly;    nanomaterials;    hybridization;    peptide;    streptavidin;   

DOI  :  10.3390/nano11123307

来源: DOAJ

【 摘 要 】

The physiochemical properties of nanomaterials have a close relationship with their status in solution. As a result of its better simplicity than that of pre-assembled aggregates, the in situ assembly of nanomaterials has been integrated into the design of electrochemical biosensors for the signal output and amplification. In this review, we highlight the significant progress in the in situ assembly of nanomaterials as the nanolabels for enhancing the performances of electrochemical biosensors. The works are discussed based on the difference in the interactions for the assembly of nanomaterials, including DNA hybridization, metal ion–ligand coordination, metal–thiol and boronate ester interactions, aptamer–target binding, electrostatic attraction, and streptavidin (SA)–biotin conjugate. We further expand the range of the assembly units from nanomaterials to small organic molecules and biomolecules, which endow the signal-amplified strategies with more potential applications.

【 授权许可】

Unknown