Human Stool Metabolome Differs upon 24 h Blood Pressure Levels and Blood Pressure Dipping Status: A Prospective Longitudinal Study

Metabolites

Pascal de Tullio¹  Arianna Cirillo¹  Julie Descy²  Pierrette Melin²  Jean-Marie Krzesinski³  François Jouret³  Annie Saint-Remy³  Justine Huart³  Georges Daube⁴  Bernard Taminiau⁴ 

[1] Center for Interdisciplinary Research on Medicines (CIRM), Metabolomics Group, University of Liège, B-4000 Liège, Belgium;Clinical Microbiology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, Belgium;Division of Nephrology, University of Liège Hospital (ULg CHU), University of Liège, B-4000 Liège, Belgium;Fundamental and Applied Research Center for Animal & Health (FARAH), Veterinary Public Health, University of Liège, B-4000 Liège, Belgium;

关键词: arterial hypertension;    dipping status;    gut microbiota;    short chain fatty acids;    acetate;    butyrate;   

DOI  :  10.3390/metabo11050282

来源: DOAJ

【 摘 要 】

Dysbiosis of gut microbiota (GM) has been involved in the pathophysiology of arterial hypertension (HT), via a putative role of short chain fatty acids (SCFAs). Its role in the circadian regulation of blood pressure (BP), also called “the dipping profile”, has been poorly investigated. Sixteen male volunteers and 10 female partners were subjected to 24 h ambulatory BP monitoring and were categorized in normotensive (NT) versus HT, as well as in dippers versus non-dippers. Nuclear magnetic resonance (NMR)-based metabolomics was performed on stool samples. A 5-year comparative follow-up of BP profiles and stool metabolomes was done in men. Significant correlations between stool metabolome and 24 h mean BP levels were found in both male and female cohorts and in the entire cohort (R² = 0.72, R² = 0.79, and R² = 0.45, respectively). Multivariate analysis discriminated dippers versus non-dippers in both male and female cohorts and in the entire cohort (Q² = 0.87, Q² = 0.98, and Q² = 0.68, respectively). Fecal amounts of acetate, propionate, and butyrate were higher in HT versus NT patients (p = 0.027; p = 0.015 and p = 0.015, respectively), as well as in non-dippers versus dippers (p = 0.027, p = 0.038, and p = 0.036, respectively) in the entire cohort. SCFA levels were significantly different in patients changing of dipping status over the 5-year follow-up. In conclusion, stool metabolome changes upon global and circadian BP profiles in both genders.

【 授权许可】

Unknown