Enhancement of Adjuvant Functions of Natural Killer T Cells Using Nanovector Delivery Systems: Application in Anticancer Immune Therapy

Frontiers in Immunology

François Trottein⁴  Reem Ghinnagow⁴  Elodie Macho-Fernandez⁴  Christelle Faveeuw⁴  Luis Javier Cruz⁵ 

[1] Centre National de la Recherche Scientifique, UMR 8204, Lille, France;Hospitalier Universitaire de Lille, Lille, France;Institut National de la Santé et de la Recherche Médicale U1019, Lille, France;Institut Pasteur de Lille, Lille, France;Translational Nanobiomaterials and Imaging, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands;Univ. Lille, U1019 – UMR 8204 – CIIL – Centre d’Infection et d’Immunité de Lille, Lille, France;

关键词: natural killer T cells;    adjuvant;    α-galactosylceramide;    CTL response;    nanovaccines;    dendritic cells;   

DOI  :  10.3389/fimmu.2017.00879

来源: DOAJ

【 摘 要 】

Type I natural killer T (NKT) cells have gained considerable interest in anticancer immune therapy over the last decade. This “innate-like” T lymphocyte subset has the unique ability to recognize foreign and self-derived glycolipid antigens in association with the CD1d molecule expressed by antigen-presenting cells. An important property of these cells is to bridge innate and acquired immune responses. The adjuvant function of NKT cells might be exploited in the clinics. In this review, we discuss the approaches currently being used to target NKT cells for cancer therapy. In particular, we highlight ongoing strategies utilizing NKT cell-based nanovaccines to optimize immune therapy.

【 授权许可】

Unknown