Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

BMC Ophthalmology

Nan Jin¹  Ruxia Pei¹  Bei Du¹  Guihua Liu¹  Ruihua Wei¹  Chengcheng Jin¹  Hua Rong¹  Di Wang¹ 

[1] Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science;

关键词: Corvis ST;    Corneal biomechanics;    Anterior segment parameters;    Stress-strain index;    Chinese population;   

DOI  :  10.1186/s12886-020-01704-6

来源: DOAJ

【 摘 要 】

Abstract Background To investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI. Methods A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis. Results The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β = 0.526, P < 0.001), axial length (AL) (β = − 0.541, P < 0.001), intraocular pressure (IOP) (β = 0.326, P < 0.001) and steepest radius of anterior corneal curvature (RsF) (β = 0.229, P < 0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P > 0.05 for each). Conclusions SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.

【 授权许可】

Unknown