Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

BMC Ophthalmology

Nan Jin¹  Guihua Liu¹  Ruihua Wei¹  Bei Du¹  Di Wang¹  Ruxia Pei¹  Hua Rong¹  Chengcheng Jin¹ 

[1] Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Postal address: 251 Fukang Road, Nankai District, Tianjin, China;Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Postal address: 251 Fukang Road, Nankai District, Tianjin, China;

关键词: Corvis ST;    Corneal biomechanics;    Anterior segment parameters;    Stress-strain index;    Chinese population;   

DOI  :  10.1186/s12886-020-01704-6

来源: Springer

【 摘 要 】

BackgroundTo investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI.MethodsA total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student’s t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis.ResultsThe mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66–1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β = 0.526, P < 0.001), axial length (AL) (β = − 0.541, P < 0.001), intraocular pressure (IOP) (β = 0.326, P < 0.001) and steepest radius of anterior corneal curvature (RsF) (β = 0.229, P < 0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P > 0.05 for each).ConclusionsSSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.

【 授权许可】

CC BY