Resistance to Antibiotics in Thermophilic Campylobacters

Frontiers in Medicine

Biljana Miljković-Selimović¹  Vladimir Biočanin²  Ema Aleksić²  Zoran Tambur²  Stevan Avramov³  Nikola Aleksić⁴ 

[1] Faculty of Medicine, University of Niš, Niš, Serbia;Faculty of Stomatology Pancevo, University Business Academy in Novi Sad, Pančevo, Serbia;Institute for Biological Research “Siniša Stanković,” University of Belgrade, Belgrade, Serbia;Institute for Cardiovascular Disease “Dedinje, ”Belgrade, Serbia;

关键词: campylobacter;    antibiotic resistance;    mechanisms of resistance;    bacterial enterocolitis;    significance of resistant strains;   

DOI  :  10.3389/fmed.2021.763434

来源: DOAJ

【 摘 要 】

Campylobacter jejuni (C. jejuni) is one of the most frequent causes of bacterial enterocolitis globally. The disease in human is usually self-limiting, but when complications arise antibiotic therapy is required at a time when resistance to antibiotics is increasing worldwide. Mechanisms of antibiotic resistance in bacteria are diverse depending on antibiotic type and usage and include: enzymatic destruction or drug inactivation; alteration of the target enzyme; alteration of cell membrane permeability; alteration of ribosome structure and alteration of the metabolic pathway(s). Resistance of Campylobacter spp. to antibiotics, especially fluoroquinolones is now a major public health problem in developed and developing countries. In this review the mechanisms of resistance to fluoroquinolones, macrolides, tetracycline, aminoglycoside and the role of integrons in resistance of Campylobacter (especially at the molecular level) are discussed, as well as the mechanisms of resistance to β-lactam antibiotics, sulphonamides and trimethoprim. Multiple drug resistance is an increasing problem for treatment of campylobacter infections and emergence of resistant strains and resistance are important One Health issues.

【 授权许可】

Unknown