Experimental study on gastroprotective efficacy and mechanisms of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn. in different experimental models

Journal of Functional Foods

Adithan Aravinthan¹  Jong-Hoon Kim¹  Paulrayer Antonisamy¹  Sung Cheol Lee²  Savarimuthu Ignacimuthu³  Ki Choon Choi⁴  Arul Albert-Baskar⁵  Pandurangan Subash-Babu⁶  Ali A. Alshatwi⁶ 

[1] College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, 5459679 Gobong-ro, Iksan-city, Jeollabuk-Do, Republic of Korea;Department of Sports Medicine, Woosuk University, 55338 Samnye-ro, Samnye-eup, Wanju-gun, Jeollabuk-do, Republic of Korea;Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India;Grassland and Forage Division, RDA, National Institute of Animal Science, Seonghwan-Eup, Cheonan-Si, Chungnam 330-801, Republic of Korea;Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea;Molecular Biology Research Lab, Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University, Riyadh 11451, Saudi Arabia;

关键词: Gastroprotective activity;    Ethanol-induced gastric injury;    Oxidative stress;    Apoptosis;    LUT7G;    Ophiorrhiza mungos;   

DOI  :  

来源: DOAJ

【 摘 要 】

The gastroprotective effect of luteolin-7-O-glucoside (LUT7G) on different ulcer models using rats including the indomethacin model, the ethanol-induced gastric ulcer model and the Shay ulcer model was examined. The ethanol-induced ulcer group showed significant increases in MPO, NO, iNOS, MMP-2, MMP-9, caspase-3, apoptosis, IL-6, TNF-α, IKK, NF-κB p65, and ICAM-1 and declines in PGE2, arginase, SOD, GSH, mucin, IL-10, eNOS, COX-1, HSP-70, and IκBα levels. However, LUT7G (25 mg/kg) pretreatment significantly reverted the pathophysiological levels of these biomarkers to near normal levels. The gastroprotective activity of LUT7G was abolished by pretreatment with SC560, rofecoxib, and L-NAME, demonstrating the participation of COX and NOS in LUT7G-facilitated gastroprotection against ethanol-induced ulcers. Convincingly, LUT7G (25 mg/kg) provided protective effects in the rat gastric mucosa against ethanol-induced gastric injury at least in part to antisecretory, anti-inflammatory, antioxidative, and antiapoptotic activity, and augmentation of PGE2, mucin and HSP-70 synthesis.

【 授权许可】

Unknown