Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products

Frontiers in Cell and Developmental Biology

Yubing Zhu¹  Chen Xu¹  Jiye Aa¹  Huiwen Mu¹  Zhaoyi Tan¹  Chun Ge²  Xintong Huang²  Dong Feng²  Shaojun Zheng²  Sujie Zhang³  Jianjun Zou³ 

[1] Clinical Pharmacy, China Pharmaceutical University, Nanjing, China;;Department of Clinical Pharmacy, School of Basic Medicine &Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China;

关键词: iron homeostasis;    lipid peroxidation;    redox signaling;    cancer;    neurodegenerative diseases;    natural products;   

DOI  :  10.3389/fcell.2021.774957

来源: DOAJ

【 摘 要 】

Ferroptosis, a newly discovered form of regulatory cell death (RCD), has been demonstrated to be distinct from other types of RCD, such as apoptosis, necroptosis, and autophagy. Ferroptosis is characterized by iron-dependent lipid peroxidation and oxidative perturbation, and is inhibited by iron chelators and lipophilic antioxidants. This process is regulated by specific pathways and is implicated in diverse biological contexts, mainly including iron homeostasis, lipid metabolism, and glutathione metabolism. A large body of evidence suggests that ferroptosis is interrelated with various physiological and pathological processes, including tumor progression (neuro)degenerative diseases, and hepatic and renal failure. There is an urgent need for the discovery of novel effective ferroptosis-modulating compounds, even though some experimental reagents and approved clinical drugs have been well documented to have anti- or pro-ferroptotic properties. This review outlines recent advances in molecular mechanisms of the ferroptotic death process and discusses its multiple roles in diverse pathophysiological contexts. Furthermore, we summarize chemical compounds and natural products, that act as inducers or inhibitors of ferroptosis in the prevention and treatment of various diseases. Herein, it is particularly highlighted that natural products show promising prospects in ferroptosis-associated (adjuvant) therapy with unique advantages of having multiple components, multiple biotargets and slight side effects.

【 授权许可】

Unknown