Therapeutic Implications of Ferroptosis in Renal Fibrosis

Frontiers in Molecular Biosciences

Yanhua Mou¹  Ruoyun Tan²  Yao Zhang²  Chuanjian Suo²  Jianjian Zhang²  Zengjun Wang²  Min Gu³  Hai Zhou³ 

[1] Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China;Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China;

关键词: renal fibrosis;    ferroptosis;    iron homeostasis;    lipid peroxidation;    programmed cell death;   

DOI  :  10.3389/fmolb.2022.890766

来源: DOAJ

【 摘 要 】

Renal fibrosis is a common feature of chronic kidney disease (CKD), and can lead to the destruction of normal renal structure and loss of kidney function. Little progress has been made in reversing fibrosis in recent years. Ferroptosis is more immunogenic than apoptosis due to the release and activation of damage-related molecular patterns (DAMPs) signals. In this paper, the relationship between renal fibrosis and ferroptosis was reviewed from the perspective of iron metabolism and lipid peroxidation, and some pharmaceuticals or chemicals associated with both ferroptosis and renal fibrosis were summarized. Other programmed cell death and ferroptosis in renal fibrosis were also firstly reviewed for comparison and further investigation.

【 授权许可】

Unknown