Higher availability of α4β2 nicotinic receptors (nAChRs) in dorsal ACC is linked to more efficient interference control

NeuroImage

Lia Antico¹  Michael Wissmeyer²  Patrik Vuilleumier³  Yann Seimbille⁴  Valentina Garibotto⁵  Swann Pichon⁶  Fabienne Picard⁷  Osman Ratib⁷  Sven Haller⁷ 

[1] Corresponding author. Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.;Distance Learning University, Brig, Switzerland;Faculty of Medicine, Geneva University, Geneva, Switzerland;Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland;Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland;Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland;Nuclear Medicine and Molecular Imaging Division, Department of Medical Imaging, University Hospitals of Geneva, Geneva, Switzerland;

关键词: α4β2 nicotinic receptors;    PET;    F-A-85380;    Stroop;    Interference control;    ACC;   

DOI  :  

来源: DOAJ

【 摘 要 】

Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the human brain and play an important role in the neuromodulation of brain networks implicated in attentional processes. Previous work in humans showed that heteromeric α4β2 nAChRs are abundant in the cingulo-insular network underlying attentional control. It has been proposed that cholinergic neuromodulation by α4β2 nAChRs is involved in attentional control during demanding tasks, when additional resources are needed to minimize interference from task-irrelevant stimuli and focus on task-relevant stimuli. Here we investigate the link between the availability of α4β2 nAChRs in the cingulo-insular network and behavioral measures of interference control using two versions of the Stroop paradigm, a task known to recruit cingulo-insular areas. We used a previously published PET dataset acquired in 24 non-smoking male subjects in the context of a larger study which investigated the brain distribution of nAChRs in two clinical groups using 2-[(18)F]F-A-85380 PET. We found that higher availability of α4β2 nAChRs in the dorsal anterior cingulate cortex (ACC) predicted better interference control independently of group and age. In line with animal models, our results support the view that the availability of α4β2 nAChRs in the dorsal ACC is linked with more efficient attentional control.

【 授权许可】

Unknown