Anti-inflammatory, analgesic and antioxidant potential of the stem bark of Spondias mangifera Willd.

Archives of Biological Sciences

关键词: Amora;    inflammation;    pain;    herbal remedies;    carrageenan challenge;   

DOI  :  10.2298/ABS1102413S

来源: DOAJ

【 摘 要 】

The anti-inflammatory and analgesic activities of the ethyl acetate (EAFSM)and n-butanol (NBFSM) fractions of the alcoholic extract of S. mangifera barkwere evaluated using carrageenan-induced rat paw edema and by the tail-flickmethod in rats. The radical scavenging activity of the ethanolic extract,aqueous extract and fractions was determined with the DPPH radical scavengingcapacity assay. Two fractions of the alcoholic extract, EAFSM and NBFSM, atdoses of 75, 150, 300 mg/kg b.w. administered orally, showed a significantreduction in paw volume when compared with the respective control groupchallenged by carrageenan. Different doses of extract fractions also showed asignificant prolongation of the tail-flick latency of the rat (P<0.01).Different concentrations of alcoholic, aqueous extracts and fractions ofalcoholic extract showed significant free radical scavenging capacity againstDPPH generated free radicals.

【 授权许可】

Unknown