| Administración sistémica adjunta de moxifloxacina versus ciprofloxacina más metronidazol en el tratamiento de periodontitis crónica con presencia de bacilos entéricos Gram negativos: . Efectos clínicos y microbiológicos</td>
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<td colspan="2" class="text5">关键词:
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"antimicrobianos"'>antimicrobianos</a>;
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"microbiología"'>microbiología</a>;
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"periodontitis"'>periodontitis</a>;
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"bacilos entéricos Gram negativos"'>bacilos entéricos Gram negativos</a>;
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"antimicrobial(s)"'>antimicrobial(s)</a>;
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"microbiology"'>microbiology</a>;
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"periodontitis"'>periodontitis</a>;
<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oakeywords:"Gram-negative enteric rods"'>Gram-negative enteric rods</a>;
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<td class="text2" colspan="2" style="color: #2575A5;">DOI : </td>
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<td colspan="2" class="text5" style="color: #2575A5;">来源:<a
href='http://oa.las.ac.cn/oainone/service/browseall/viewmore?ptype=JA&q= AND oasourcestr:"DOAJ"'>
DOAJ</a></td>
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<h6>【 摘 要 】</h6>
<p style="text-align: justify; text-indent: 2em;">
INTRODUCCIÓN: los hallazgos clínicos preliminares indican que las lesiones periodontales asociadas a bacilos entéricos Gram negativos no responden al tratamiento convencional. Los objetivos del presente estudio fueron evaluar y comparar los efectos clínicos y microbiológicos del raspaje y alisado radicular (RAR) combinado con la administración sistémica de moxifloxacina (MOX) o ciprofloxacina mas metronidazol (CIPRO + MET), en el tratamiento de sujetos con periodontitis crónica. MÉTODOS: en este ensayo clínico participaron 76 pacientes, divididos en dos grupos. Los sujetos se trataron con RAR más MOX (Grupo MOX; n = 38) o RAR más CIPRO + MET (Grupo CIPRO + MET; n = 38). Los datos clínicos y microbiológicos se registraron a nivel base, y a los 3 y 6 meses después del tratamiento. Los cambios significativos en los parámetros clínicos y microbiológicos, intra e inter grupos, se midieron utilizando las pruebas de Mann-Whitney y Wilcoxon, respectivamente. RESULTADOS: después de seis meses, los dos grupos de tratamiento presentaron una reducción significativa en la profundidad de sondaje y en el sangrado al sondaje, además de una ganancia en la inserción clínica (P < 0,05). Se observó disminución estadísticamente significativa de la proporción de sitios > 6 mm. No se identificaron entéricos ni Aggregatibacter actinomycetemcomitans en ninguno de los grupos, después de la terapia. CONCLUSIONES: este estudio proporciona evidencia del beneficio adjunto de MOX o CIPROMET al RAR, en pacientes con periodontitis crónica que presentan entéricos. Sin embargo, MOX puede ser el antibiótico de elección en vista de los pocos efectos adversos ocasionados y debido a su dosificación solo una vez al día.<br>INTRODUCTION: preliminary clinical findings indicate that periodontal lesions associated with Gram-negative enteric rods do not respond to conventional treatment modalities. The aim of the present study was to evaluate and compare the clinical and microbiological effects of scaling and root planing (SRP) combined with systemic administration of moxifloxacin (MOX) or ciprofloxacin plus metronidazole (CIPRO + MET) in the treatment of chronic periodontitis. METHODS: seventy-six patients participated in this randomized clinical trial, and they were divided into two groups. Subjects were treated with SRP plus adjunctive MOX (MOX group; n = 38) or SRP plus adjunctive CIPRO + MET (CIPRO + MET GROUP; n = 38). Clinical and microbiological data were recorded at baseline and at 3 and 6 months after treatment. The significant changes in clinical and microbiological parameters between and within the groups were measured using the Mann-Whitney test and Wilcoxon’s rank test respectively. RESULTS: after six months, both treatment groups showed a significant reduction in probing depth and bleeding on probing (P < 0.05) and better clinical attachment. A statistically significant reduction of the proportion of sites > 6 mm was also observed. Gram-negative enteric rods and Aggregatibacter actinomycetemcomitans were not identified in either group six months after baseline. CONCLUSIONS: this study provides evidence of the benefit of using MOX or CIPRO+MET as adjunct to SRP in patients with chronic periodontitis harboring Gram-negative enteric rods. However, MOX may be the antibiotic of choice in view of its few adverse effects and single dose treatment per day.</p>
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