Production of C2–C4 diols from renewable bioresources: new metabolic pathways and metabolic engineering strategies

Biotechnology for Biofuels

Zhen Chen¹  Dehua Liu¹  Ye Zhang¹ 

[1] Department of Chemical Engineering, Tsinghua University;

关键词: Diols;    Bioresource;    Pathway design;    New metabolic pathway;    Metabolic engineering;   

DOI  :  10.1186/s13068-017-0992-9

来源: DOAJ

【 摘 要 】

Abstract C2–C4 diols classically derived from fossil resource are very important bulk chemicals which have been used in a wide range of areas, including solvents, fuels, polymers, cosmetics, and pharmaceuticals. Production of C2–C4 diols from renewable resources has received significant interest in consideration of the reducing fossil resource and the increasing environmental issues. While bioproduction of certain diols like 1,3-propanediol has been commercialized in recent years, biosynthesis of many other important C2–C4 diol isomers is highly challenging due to the lack of natural synthesis pathways. Recent advances in synthetic biology have enabled the de novo design of completely new pathways to non-natural molecules from renewable feedstocks. In this study, we review recent advances in bioproduction of C2–C4 diols, focusing on new metabolic pathways and metabolic engineering strategies being developed. We also discuss the challenges and future trends toward the development of economically competitive processes for bio-based diol production.

【 授权许可】

Unknown