Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism

International Journal of Molecular Sciences

Toshio Suda¹  Hiroko Shiozaki²  Makiko Mochizuki-Kashio³  Ayako Nakamura-Ishizu³ 

[1] Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, Singapore 117599, Singapore;Department of Hematology, Tokyo Women’s Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan;Microanatomy and Developmental Biology, Tokyo Women’s Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan;

关键词: hematopoietic stem cells;    ROS;    mitochondria;    lysosome;    autophagy;    folliculin;   

DOI  :  10.3390/ijms22094627

来源: DOAJ

【 摘 要 】

Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for the determination of HSC cell fate. This review encompasses the current understanding of anaerobic metabolism in HSCs as well as the emerging roles of mitochondrial metabolism and lysosomal regulation for hematopoietic homeostasis.

【 授权许可】

Unknown