AIDS-related Cryptococcus neoformans choroiditis

IDCases

Sarah Reingold¹  Ann D. Thor²  Jose R. Castillo-Mancilla³  Andrés F. Henao-Martinez⁴  Gregory S. Canfield⁴  Andrea Ho⁵  Daniel B. Chastain⁶  Paula E. Pecen⁷  Kristen DeSanto⁷  Carlos Franco-Paredes⁸ 

[1] Corresponding authors at: Division of Infectious Disease, University of Colorado School of Medicine, 1635 Aurora Court, Mailstop B-163, Aurora, CO, 80045, United States.;Division of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States;Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Albany, GA, United States;Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, United States;Division of Internal Medicine, University of Colorado School of Medicine, Aurora, CO, United States;Division of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, United States;Division of Pathology, University of Colorado School of Medicine, Aurora, CO, United States;Health Sciences Library, University of Colorado School of Medicine, Aurora, CO, United States;

关键词: Cryptococcal;    Cryptococcus;    Choroiditis;    Toxoplasma;    HIV and AIDS;   

DOI  :  

来源: DOAJ

【 摘 要 】

We describe a case of Cryptococcal choroiditis in a person with advanced HIV/AIDS. A 29-year-old male with AIDS presented with fever, photophobia, and ataxia secondary to cryptococcal and toxoplasma meningoencephalitis. Dilated fundoscopic examination revealed bilateral and multifocal posterior infiltrates consistent with cryptococcal choroiditis. Treatment with parenteral and intravitreal liposomal amphotericin B, oral flucytosine, and oral trimethoprim-sulfamethoxazole led to resolution of his symptoms and improvement in his vision. Our case documents a rare, intraocular opportunistic infection and highlights the importance of ophthalmologic examination in immunocompromised hosts with visual symptoms and invasive fungal infection. We discuss diagnostic and treatment considerations in cryptococcal choroiditis.

【 授权许可】

Unknown