Tip-Viscid Electrohydrodynamic Jet 3D Printing of Composite Osteochondral Scaffold

Nanomaterials

Dazhi Wang¹  Chuanhe Dong²  Xiaoying Wang³  Yuguo Cui⁴  Fangyuan Zhang⁴  Hairong Chen⁴  Kai Li⁴  Aibing Yu⁴ 

[1] Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian 116024, China;Research Center of Intelligent Industrial Robot, Chinese Academy of Sciences, Jinan 250100, China;School of Civil and Environmental Engineering, Ningbo University, Ningbo 315211, China;School of Mechanical Engineering and Mechanics, Ningbo University, Ningbo 315211, China;

关键词: 3D printing;    electrohydrodynamic jet;    thermal field;    fluid viscosity;    osteochondral scaffold;   

DOI  :  10.3390/nano11102694

来源: DOAJ

【 摘 要 】

A novel method called tip-viscid electrohydrodynamic jet printing (TVEJ), which produces a viscous needle tip jet, was presented to fabricate a 3D composite osteochondral scaffold with controllability of fiber size and space to promote cartilage regeneration. The tip-viscid process, by harnessing the combined effects of thermal, flow, and electric fields, was first systematically investigated by simulation analysis. The influences of process parameters on printing modes and resolutions were investigated to quantitatively guide the fabrication of various structures. 3D architectures with high aspect ratio and good interlaminar bonding were printed, thanks to the stable fine jet and its predictable viscosity. 3D composite osteochondral scaffolds with controllability of architectural features were fabricated, facilitating ingrowth of cells, and eventually inducing homogeneous cell proliferation. The scaffold’s properties, which included chemical composition, wettability, and durability, were also investigated. Feasibility of the 3D scaffold for cartilage tissue regeneration was also proven by in vitro cellular activities.

【 授权许可】

Unknown