The Relevance of the Bacterial Microbiome, Archaeome and Mycobiome in Pediatric Asthma and Respiratory Disorders

Cells

Frank Schult¹  Stefan Wirth¹  Anton Pembaur²  Jan Postberg²  Aliyah Bellm³  Friedrich Paulsen⁴  Anja Ehrhardt⁵  Eleni Buedding⁶  Malik Aydin⁶  Carolin Baehren⁶ 

[1] Center for Child and Adolescent Medicine, Center for Clinical and Translational Research (CCTR), Helios University Hospital Wuppertal, Witten/Herdecke University, 42283 Wuppertal, Germany;Clinical Molecular Genetics and Epigenetics, Faculty of Health, Center for Biomedical Education & Research (ZBAF), Helios University Hospital Wuppertal, Witten/Herdecke University, Alfred-Herrhausen-Str. 50, 58448 Witten, Germany;Helios Hospital Krefeld, Children’s Hospital, Teaching Hospital of RTWH University Hospital Aachen, 47805 Krefeld, Germany;Institute of Functional and Clinical Anatomy, Friedrich Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany;Institute of Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, Witten/Herdecke University, 58453 Witten, Germany;Laboratory of Experimental Pediatric Pneumology and Allergology, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany;

关键词: microbiome;    archaea;    fungi;    nasopharynx;    oropharynx;    asthma;   

DOI  :  10.3390/cells11081287

来源: DOAJ

【 摘 要 】

Bacteria, as well as eukaryotes, principally fungi, of the upper respiratory tract play key roles in the etiopathogenesis of respiratory diseases, whereas the potential role of archaea remains poorly understood. In this review, we discuss the contribution of all three domains of cellular life to human naso- and oropharyngeal microbiomes, i.e., bacterial microbiota, eukaryotes (mostly fungi), as well as the archaeome and their relation to respiratory and atopic disorders in infancy and adolescence. With this review, we aim to summarize state-of-the-art contributions to the field published in the last decade. In particular, we intend to build bridges between basic and clinical science.

【 授权许可】

Unknown