Butter oil (ghee) enrichment with aromatic plants: Chemical characterization and effects on fibroblast migration in an in-vitro wound healing model

Arabian Journal of Chemistry

Sauro Vittori¹  Franks Kamgang Nzekoue²  Afraa Maiza³  Makrem Afif³  Giovanni Caprioli⁴  Dennis Fiorini⁵  Sami Fattouch⁵  Michela Buccioni⁵  Tesmine Ghazouani⁵  Gabriella Marucci⁵  Aleix Martì Navia⁵  Filippo Maggi⁶ 

[1] Corresponding author.;Faculty of Sciences of Bizerte, University of Carthage, Tunis, Tunisia;Food and Molecular Biochemistry Laboratory, National Institute of Applied Sciences and Technology (INSAT), University of Carthage, North Urban Center, BP 676-1080, Tunis Cedex, 1080, Tunisia;National Institute of Applied Sciences and Technology (INSAT), Department of Biology Laboratory of Plant Biotechnology North Urban Center, BP 676, 1080 Tunis Cedex, Tunisia;School of Pharmacy, University of Camerino, Via Sant’Agostino 1, 62032 Camerino, Italy;School of Science and Technology, Chemistry Division, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy;

关键词: Fibroblast migration;    Ghee;    Maceration;    Natural antioxidant;    Nutritional composition;    Wound healing;   

DOI  :  

来源: DOAJ

【 摘 要 】

Ghee is a dairy product widely consumed in India, north-Africa, and Middle East countries, having beneficial pharmacological effects. This study aims to characterize the effects of aromatic plants addition (rosemary and clove) on the nutritional, volatile and oxidative profile of cow ghee and to evaluate the effect of flavored ghee on the fibroblasts migration during wound healing in vitro assay. Two flavored ghee products were obtained by adding clove (CG) and rosemary (RG) as aromatic plants through maceration in cattle traditional ghee (BT). It was revealed that enriched ghee samples had significantly lower peroxide values (6.76 and 6.80 meqO2 /kg) compared to control samples (8.20 meqO2 /kg). Moreover, the addition of rosemary and clove change the volatile profile, and increased the retinol levels of ghee (BT: 1.3 mg/kg; CG: 1.9 mg/kg; and RG: 3.05 mg/kg). Liquid-chromatography analyses revealed the presence of targeted phenolic compounds such as carnosic acid, rutin and gallic acid in CG and RG, showing thus, the transfer of polyphenols from aromatic plants into the ghee matrix. On the other hand, the fatty acid composition of ghee remained unchanged. The major components of the prepared ghee samples contributed to rising significantly the human fibroblast migration in wound healing in vitro assay. The results obtained underline that the flavored ghee samples could improve skin regeneration, making them potentials therapeutic ingredients in skincare formulations.

【 授权许可】

Unknown