Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis

International Journal of Molecular Sciences

Neng Zhu¹  Xi-Long Zheng²  Bao-Xue Ao²  Chan Liu²  Li Qin²  Ke Du²  Ya-Ning Shi²  Jian-Xiong Chen²  Duan-Fang Liao² 

[1] Department of Urology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410208, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China;

关键词: caveolae;    caveolin-1;    reverse cholesterol transport;    inflammation;    atherosclerosis;   

DOI  :  10.3390/ijms17030429

来源: DOAJ

【 摘 要 】

Lipid disorder and inflammation play critical roles in the development of atherosclerosis. Reverse cholesterol transport is a key event in lipid metabolism. Caveolae and caveolin-1 are in the center stage of cholesterol transportation and inflammation in macrophages. Here, we propose that reverse cholesterol transport and inflammation in atherosclerosis can be integrated by caveolae and caveolin-1.

【 授权许可】

Unknown