Loss of p27Kip1 expression in high grade human prostate adenocarcinoma

Journal of BioScience and Biotechnology

CHONG PEI PEI¹  MALINA OSMAN²  NORAINI MAT DUSA³  MOHD ROHAIZAD MD. RODUAN⁴  NORHAFIZAH MOHTARRUDIN⁴ 

[1] Department of Biomedical Sciences;Department of Medical Microbiology& Parasitology, Faculty of Medicine andHealth Sciences, University Putra Malaysia, 43400 Serdang,Selangor, Malaysia;Department of Pathology , HospitalKuala Lumpur, Jalan Pahang, 50588Kuala Lumpur, Malaysia;Department of Pathology Faculty of Medicine and HealthSciences,University Putra Malaysia,43400 Serdang, Selangor, Malaysia;

关键词: carcinogenesis;    prostate adenocarcinoma (PCa);    benign prostatic hyperplasia (BPH);    p27Kip1;   

DOI  :  

来源: DOAJ

【 摘 要 】

p27Kip1 has been hypothesized to play a major role in carcinogenesis. Most of the published data reported that loss of p27Kip1 expression was strongly associated with development and progression of tumour. The purpose of this study was to analyze p27Kip1 expression in normal, benign and malignant prostate cancer tissues and their association with the clinicopathological parameters. The expression of p27Kip1 was evaluated by an immunohistochemistry method. p27Kip1 expression was significantly higher in normal and benign prostate tissues (P<0.01). In contrast, some malignant tissues had no p27Kip1 expression and most had weak p27Kip1 expression. p27Kip1 expression was found to be decreased significantly with increasing Gleason scores (P=0.003). Most of prostate adenocarcinomas (PCa) with Gleason 8 and 9 showed loss of p27Kip1 expression. The expression was also positively correlated with prostate specific antigen level and age in PCa group (P=0.003 and 0.043 respectively), whereas no association was found between the p27Kip1 expression with tumour amount and age in benign prostatic hyperplasia group. This study suggests that loss of p27Kip1expression is essential during development and progression of prostate cancer.

【 授权许可】

Unknown