Applied Sciences | |
Evaluation of Classical Mathematical Models of Tumor Growth Using an On-Lattice Agent-Based Monte Carlo Model | |
Antonio M. Lallena1  Mercedes Villalobos1  Samuel Ruiz-Arrebola2  Damián Guirado3  | |
[1] Instituto de Investigación Biosanitaria (ibs.GRANADA), Universidad de Granada, E-18016 Granada, Spain;Servicio de Oncología Radioterápica, Hospital Universitario Marqués de Valdecilla, E-39008 Santander, Spain;Unidad de Radiofísica, Hospital Universitario Clínico San Cecilio, E-18016 Granada, Spain; | |
关键词: on-lattice agent-based models; classical tumor growth models; exponential; Gompertz; logistic; Bertalanffy; | |
DOI : 10.3390/app11115241 | |
来源: DOAJ |
【 摘 要 】
Purpose: To analyze the capabilities of different classical mathematical models to describe the growth of multicellular spheroids simulated with an on-lattice agent-based Monte Carlo model that has already been validated. Methods: The exponential, Gompertz, logistic, potential, and Bertalanffy models have been fitted in different situations to volume data generated with a Monte Carlo agent-based model that simulates the spheroid growth. Two samples of pseudo-data, obtained by assuming different variability in the simulation parameters, were considered. The mathematical models were fitted to the whole growth curves and also to parts of them, thus permitting to analyze the predictive power (both prospective and retrospective) of the models. Results: The consideration of the data obtained with a larger variability of the simulation parameters increases the width of the
【 授权许可】
Unknown