Oxidative and Epigenetic Changes and Gut Permeability Response in Early-Treated Chickens with Antibiotic or Probiotic

Animals

Anna Stępniowska¹  Katarzyna Ognik¹  Paweł Konieczka²  Jan Jankowski² 

[1] Department of Biochemistry and Toxicology, Faculty of Animal Science and Bioeconomy, University of Life Sciences, Akademicka 13, 20-950 Lublin, Poland;Department of Poultry Science, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, Poland;

关键词: chicken;    antibiotic;    probiotic;    intestinal damage;   

DOI  :  10.3390/ani10122204

来源: DOAJ

【 摘 要 】

The aim of this study was to compare the effect of the use of enrofloxacin and a probiotic containing Enterococcus faecium and Bacillus amyloliquefaciens strains in the first week of life of chickens on oxidative and epigenetic changes in molecules and intestinal integrity. The three treatments were as follows: the control group received no additive in the drinking water (GC); the second group (GP) received a probiotic preparation in the drinking water during the first five days of life, providing E. faecium strain 4a1713 at 1.0 × 10⁷ CFU/L water and B. amyloliquefaciens 4b1822 at 1.0 × 10⁷ CFU/L water, the third group (GA) received an antibiotic (enrofloxacin 0.5 mL/L water) in the drinking water during the first five days of life. The use of both enrofloxacin and a probiotic containing E. faecium and B. amyloliquefaciens strains in chickens’ first week of life improved intestinal integrity and reduced inflammation and oxidative and epigenetic changes in the small intestine. This effect was evident both at 6 days of age and at the end of the rearing period.

【 授权许可】

Unknown