Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients

Respiratory Research

卷:19

A. Carmona-Olveira¹  A. J. Plata²  M. A. Martinez-Garcia³  C. Olveira⁴  A. Padilla-Galo⁵  L. Fernández de Rota-Garcia⁵  J. J. Cebrian-Gallardo⁵  A. Alvarez⁶  I. Marco-Galve⁶  F. Rivas-Ruiz⁷ 

[1] Faculty of Medicine, University of Málaga;

[2] Infectious Diseases Department, Hospital Regional Universitario de Málaga;

[3] Pneumology Department, Hospital Universitario La Fe;

[4] Pneumology Department, IBIMA (Institute for biomedical research of Málaga), Hospital Regional Universitario de Málaga/ University of Málaga;

[5] Pneumology Unit. Agencia Sanitaria Costa del Sol;

[6] Radiology Deparment. Hospital de Alta Resolución de Benalmádena;

[7] Research Unit. Red de Investigación en Servicios de Salud en Enfermedades Crónicas, REDISSEC (Spanish healthcare network for chronic diseases), Agencia Sanitaria Costa del Sol;

关键词: Asthma;    Bronchiectasis;    Prevalence;    Risk factors;    NOPES;   

DOI  :  10.1186/s12931-018-0746-7

来源: DOAJ

【 摘 要 】

Abstract Background Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the prevalence of bronchiectasis in uncontrolled moderate-to-severe asthma and to identify risk factors and their correlation with bronchiectasis in these patients. Methods This is a prospective study of data from consecutive patients with uncontrolled moderate-to-severe asthma. Diagnosis of bronchiectasis was based on high-resolution computed tomography. A prognostic score was developed using a logistic regression model, which was used to determine the factors associated with bronchiectasis. Results A total of 398 patients (60% with severe asthma) were included. The prevalence of bronchiectasis was 28.4%. The presence of bronchiectasis was associated with a higher frequency of chronic expectoration (OR, 2.95; 95% CI, 1.49–5.84; p = 0.002), greater severity of asthma (OR, 2.43; 95% CI, 1.29–4.57; p = 0.006), at least one previous episode of pneumonia (OR, 2.42; 95% CI, 1.03–5.69; p = 0.044), and lower levels of FeNO (OR, 0.98; 95% CI, 0.97–0.99; p = 0.016). The NOPES score was developed on the basis of these variables (FeNO[cut off point 20.5 ppb], Pneumonia, Expectoration and asthma Severity), and it ranges from 0 to 4 points, where 0 means “no risk” and 4 corresponds to “high risk”. The NOPES score yielded an AUC-ROC of 70% for the diagnosis of bronchiectasis, with a specificity of 95%. Conclusions Almost a third of the patients with uncontrolled moderate-to-severe asthma had bronchiectasis. Bronchiectasis was related to the severity of asthma, the presence of chronic expectoration, a previous history of pneumonia, and lower levels of FeNO. The NOPES score is an easy-to-use scoring system with a high prognostic value for bronchiectasis in patients with uncontrolled moderate-to-severe asthma.

【 授权许可】

Unknown