Memory, processing of emotional stimuli, and volume of limbic structures in pediatric-onset multiple sclerosis

NeuroImage: Clinical

卷:31

Christine Till¹  E. Ann Yeh²  Giulia Longoni²  Tracy L. Fabri³  Elisea De Somma³  Emily Barlow-Krelina³  Julia O'Mahony⁴  Brenda L. Banwell⁵  Micky Bacchus⁵  Ritobrato Datta⁵  Raquel E. Gur⁶  Ruben C. Gur⁶ 

[1] Perelman School of Medicine, University of Pennsylvania, United States;

[2] Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, Canada;

[3] Department of Psychology, York University, Canada;

[4] Departments of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada;

[5] Division of Neurology, Children’s Hospital of Philadelphia, United States;

[6] Penn-CHOP Lifespan Brain Institute, Departments of Psychiatry, Neurology, and Radiology, University of Pennsylvania School of Medicine, United States;

关键词: Episodic memory;    Emotion identification;    Neurocognitive testing;    Hippocampus;    Amygdala;    Thalamus;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS. Method: Sixty-five POMS participants (Mage = 18.3 ± 3.9 years; 48 female (73.8%)), average disease duration = 3.8 ± 3.8 years) and 76 age- and sex-matched controls (Mage = 18.1 ± 4.6 years; 49 female (64.5%)) completed the Penn Computerized Neurocognitive Battery (PCNB); 59 of 65 POMS participants and 69 out of 76 controls underwent 3 T MRI scanning. We derived age-adjusted Z-scores on accuracy and response time (RT) measures of episodic memory and emotion identification of the PCNB. Magnetic resonance imaging (MRI) volumetrics were normalized using the scaling factor computed by SIENAx. On PCNB tests that differed between groups, we used multiple linear regression to assess relationships between regional brain volumes and either episodic memory or emotion identification outcomes controlling for age, sex, accuracy/RT, and parental education. Results: POMS participants were slower and less accurate than controls on the episodic memory domain but did not differ from controls on emotion outcomes. At the subtest level, POMS participants showed reduced accuracy on Word Memory (p = .002) and slower performance on Face Memory (p = .04) subtests. POMS participants had smaller total and regional brain volumes of the hippocampus, amygdala, and thalamus (p values ≤ 0.01). Collapsing across groups, both hippocampal and thalamic volume were significant predictors of Word Memory accuracy; hippocampal volume (B = 0.24, SE = 0.10, p = .02) was more strongly associated with Word Memory performance than thalamic volume (B = 0.16, SE = 0.05, p = .003), though the estimate with was less precise. Conclusions: POMS participants showed reduced episodic memory performance compared to controls. Aspects of episodic memory performance were associated with hippocampal and thalamic volume. Emotion identification was intact, despite volume loss in the amygdala.

【 授权许可】

Unknown