Androgen expression & clinicopathological features in male breast cancer

Breast Cancer Management

卷:7

Miguel de la Cruz¹  Julio Abugattas¹  Jose M Cotrina¹  Jorge Dunstan¹  Lia P Rebaza¹  Gabriela Calderon¹  Luis A Bernabe²  Miluska Castillo²  Joselyn Sanchez²  Omar Mejia²  Carlos A Castaneda²  Henry Guerra³  Maria R Villa-Robles³  Henry L Gomez⁴  Nathaly Poma⁴ 

[1] 1Department of Breast Surgery, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Lima, Peru;

[2] 2Research Department, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Lima, Peru;

[3] 4Pathology Department, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Lima, Peru;

[4] 5Medical Oncology Department, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Lima, Peru;

关键词: androgen receptor;    breast cancer;    estrogen receptor;    immunohistochemistry;    lymphocytes;    male;   

DOI  :  10.2217/bmt-2017-0027

来源: DOAJ

【 摘 要 】

Aim: To investigate prognostic features in male breast cancer (MBC). Methods: Clinicopathological information from 40 MBC patients was retrospectively reviewed. Androgen receptor (AR) and estrogen receptor (ER) were prospectively stained out in 22 cases and counted through software program analysis. Results: Median age was 65.5 years; most cases were Stage II (40%), Grade II (37.5%), ER ≥10% (72.5%) and PgR ≥10% (75%). AR >10% was found in 17 of 22 cases. Although AR expression was correlated with ER, there are some cells without coexpression. Axillary node involvement was associated with DFS (p = 0.001) and age (p = 0.002) was associated with overall survival. Conclusion: ER is expressed in most MBC cases and is correlated with AR. Axillary involvement and age were associated with survival.

【 授权许可】

Unknown