Effects of wound dressing based on the combination of silver@curcumin nanoparticles and electrospun chitosan nanofibers on wound healing

Bioengineered

卷:13

Yuhua Zhu¹  Huan Sheng²  Xuejie Lun³  Chuanliang Liu⁴  Anquan Yan⁴ 

[1] Anqiu Women and Children’s Hospital;

[2] Weifang Medical University;

[3] Weifang Municipal Hospital;

[4] Weifang People’s Hospital;

关键词: wound dressing;    electrospun nanofibrous;    silver nanoparticles;    curcumin;    antibacteria;   

DOI  :  10.1080/21655979.2022.2031415

来源: DOAJ

【 摘 要 】

Healing of various skin wounds is a lengthy process and often combined with bacterial infection and scar formation. Biomimetic electrospun nanofibrous wound dressing loaded with materials that possess properties of dual antibacterial and tissue repair would be developed to address this problem. In this study, a composite chitosan electrospun nanofibrous material containing Cur@β-CD/AgNPs nanoparticles composed of silver and curcumin possessed synergic effects on antibacterial activity and wound healing. The developed functionalized silver nanoparticles showed effective activity against both Gram-negative and Gram-positive bacteria. In vivo, Cur@β-CD/AgNPs chitosan dressing displayed enhanced wound closure rates compared to commercial AquacelAg. Moreover, Cur@β-CD/AgNPs chitosan dressing contributed to the most uniform collagen distribution by Masson’s trichrome staining. In brief, Cur@β-CD/AgNPs chitosan nanofibers work as a potential wound dressing with antibacterial and antiscarring properties.

【 授权许可】

Unknown