Usefulness of pelvic ultrasonography for the diagnosis of central precocious puberty in girls

Korean Journal of Pediatrics

卷:58

Sun Hee Lee¹  Ha Young Shin²  Jung Yu²  Jae Hyun Kim²  You Sung Kim³ 

[1] Department of Pediatrics, Gil Medical Center, Graduate School of Medicine, Gacheon University of Medicine and Science, Incheon, Korea.;

[2] Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.;

[3] Department of Radiology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.;

关键词: Precocious puberty;    Diagnosis;    Pelvis;    Ultrasonography;    Girls;   

DOI  :  10.3345/kjp.2015.58.8.294

来源: DOAJ

【 摘 要 】

PurposeIt is difficult to differentiate between central precocious puberty (CPP) and premature thelarche (PT) in girls. The aim of this study was to investigate the diagnostic usefulness of pelvic ultrasonography to distinguish between CPP and PT in girls with early breast development.MethodsThis study included girls with early breast development who visited the clinic between January 2012 and December 2013. Clinical, laboratory, and pelvic ultrasonographic data were evaluated. CPP and PT were confirmed using the gonadotropin-releasing hormone stimulation test.ResultsA total of 248 girls aged 7-8 years were included, among whom 186 (75.0%) had CPP and 62 (25.0%) had PT. The uterine length, transverse diameter, fundus, volume, and cross-sectional area were significantly larger in the CPP group (uterine length, 2.45±0.50 cm vs. 2.63±0.49 cm, P=0.015; uterine volume, 0.95±0.62 cm3 vs. 1.35±0.76 cm3, P<0.001). However, there were no differences in the fundus/cervix ratio and ovarian measurements. In receiver operating characteristic analysis, a uterine volume of at least 1.07 cm3 was the most predictive parameter for CPP with an area under the curve of 0.670 (95% confidence interval, 0.593-0.747).ConclusionUterine measurements by pelvic ultrasonography in girls with early pubertal development were significantly larger in the CPP group. However, the diagnostic value of ultrasonographic parameters was not high because of a considerable overlap of values between the two groups. Therefore, pelvic ultrasonography in combination with clinical and laboratory tests may be useful to distinguish between CPP and PT in girls.

【 授权许可】

Unknown