Identification of CD4+ Conventional T Cells-Related lncRNA Signature to Improve the Prediction of Prognosis and Immunotherapy Response in Breast Cancer

Frontiers in Immunology

卷:13

You Pan¹  Shipeng Ning²  Kun Qiao²  Lei Li³  Qinghua Huang⁴  Jianbin Wu⁵ 

[1] Gynecology and Pediatrics, Fujian Medical University, Fujian, China;

[2] Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nanning, China;

[3] Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China;

[4] Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand;

[5] Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics &

关键词: long non-coding RNA;    CD4+ conventional T cells;    breast cancer;    The Cancer Genome Atlas;    prognostic signature;   

DOI  :  10.3389/fimmu.2022.880769

来源: DOAJ

【 摘 要 】

BackgroundBreast cancer (BC) is one of the most common malignancies in women, and long non-coding RNAs (lncRNAs) are key regulators of its development. T cells can recognize and kill cancer cells, and CD4+ T conventional (Tconv) cells are the main orchestrators of cancer immune function. However, research on CD4+ Tconv-related lncRNAs (CD4TLAs) prognostic signature in patients with BC is still lacking.MethodA TCGA database and a GEO database were used to collect the BC patients. Through LASSO Cox regression analysis CD4TLAs-related prognostic models were further constructed, and risk scores (RS) were generated and developed a nomogram based on CD4TLAs. The accuracy of this model was validated in randomized cohorts and different clinical subgroups. Gene set enrichment analysis (GSEA) was used to explore potential signature-based functions. The role of RS has been further explored in the tumor microenvironment (TME), immunotherapy, and chemotherapy.ResultA prognostic model based on 16 CD4TLAs was identified. High-RS was significantly associated with a poorer prognosis. RS was shown to be an independent prognostic indicator in BC patients. The low-RS group had a significant expression of immune infiltrating cells and significantly enriched immune-related functional pathways. In addition, the results of immunotherapy prediction indicated that patients with low-RS were more sensitive to immunotherapy.ConclusionsOur signature has potential predictive value for BC prognosis and immunotherapy response. The findings of this work have greatly increased our understanding of CD4TLA in BC.

【 授权许可】

Unknown