Mimiviridae, Marseilleviridae, and virophages as emerging human pathogens causing healthcare-associated infections

GMS Hygiene and Infection Control

卷:9

Kutikhin, Anton G.¹  Brusina, Elena B.¹  Yuzhalin, Arseniy E.² 

[1] Department of Epidemiology, Kemerovo State Medical Academy, Kemerovo, Russian Federation;

[2] Department of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom;

关键词: mimivirus;    mimiviridae;    marseilleviridae;    giant viruses;    virophages;    pneumonia;    healthcare-associated infections;   

DOI  :  10.3205/dgkh000236

来源: DOAJ

【 摘 要 】

[english] Aim: During the last decade it became obvious that viruses belonging toandfamilies (order Megavirales), may be potential causative agents of pneumonia. Thus, we have performed a review of the association of , , and virophages with pneumonia, particularly healthcare-associated pneumonia, and other infections of the respiratory tract. Results and discussion: According to the analysis of the published articles, viruses belonging to Mimiviridae family can be potential agents of both community-acquired and healthcare-associated pneumonia. In particular, these viruses may be associated with poor outcome in patients of intensive care units. The exact mechanism of their pathogenicity, however, still remains unclear. The discrepancies between the results obtained by serological and genomic methods could be explained by the high polymorphism of nucleotide sequences offamily representatives. Further investigations on thepathogenicity and on the determination of -caused pneumonia risk groups are required. However, the pathogenicity of the viruses belonging tofamily and virophages is unclear up to now.

【 授权许可】

Unknown