The effects of cigarette smoking extracts on cell cycle and tumor spread: novel evidence

Future Science OA

卷:5

Fabrizio Citarella¹  Aldo Pezzuto²  Ivana Croghan³  Giuseppe Tonini⁴ 

[1] Thoracic Department, AOU Sant’Andrea, Sapienza – Università di Roma, Roma, Italy;

[2] 1Cardiovascular &

[3] 2Oncology Department, Campus Bio-Medico Università di Roma, Roma, Italy;

[4] 3Department of Medicine Clinical Research Office &

关键词: apoptosis;    autophagy;    cancerization;    carcinogenesis;    cell cycle;    cigarette smoke extracts;   

DOI  :  10.2144/fsoa-2019-0017

来源: DOAJ

【 摘 要 】

Cigarette smoking is a major preventable risk factor for lung cancer, contributing to lung cancer progression and metastasis. Moreover, cigarette smoking correlates with increased metastasis frequency of pancreatic, breast and bladder cancer. The aim of this review was to examine the role of cigarette smoke extract in cell cycle and cancer progression. Clinical impact and the effects of cigarette smoke extract on carcinogenesis are discussed. 98 of the over 5000 chemicals in tobacco smoke are known carcinogens that can act on cancer genes such as K-RAS and p53. Through various mechanisms these compounds can activate molecules involved in the cell cycle, such as cyclins, and molecules involved in apoptosis and autophagy, such as Beclin-1 or LC3B. A search of the literature, including in vitro and in vivo studies, was carried out and the results summarized.

【 授权许可】

Unknown