Gut, oral and nasal microbiota and Parkinson’s disease

Microbial Cell Factories

卷:19

Liang Shen¹ 

[1] Institute of Biomedical Research, Shandong University of Technology;

关键词: Parkinson’s disease;    Gut microbiota;    Oral microbiota;    Nasal microbiota;   

DOI  :  10.1186/s12934-020-01313-4

来源: DOAJ

【 摘 要 】

Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, and in an effort to identify novel therapeutic target for this disease in recent years, human microbiota has attracted much interest. This paper briefly summarizes the main findings concerning the differences of human microbiome across several important mucosal interfaces, including nose, mouth, and gut between PD patients and controls as obtained from a total of 13 studies published since 2015, which covered a total of 943 PD patients and 831 matched controls from 6 countries. Overall, these studies supported the differences of gut microbiota between PD patients and matched controls, while significantly altered bacterial taxa among studies were not identical. Due to relatively limited number of available studies and covered patients, the associations between oral and nasal microbiota and PD remain inconclusive. The therapeutic and diagnostic potentials of gut microbiota for PD are discussed. More well-designed clinical studies recruiting large-scale PD patients are encouraged in future.

【 授权许可】

Unknown