The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks

Frontiers in Human Neuroscience

卷:16

Susan Prejawa¹  David W. Green²  Oiwi Parker Jones³  Andrea Garjardo-Vidal⁴  Adam Kenji Yamamoto⁶  Laura Mancini⁶  Tarek A. Yousry⁶  Rebecca Pope⁹  Cathy J. Price⁹  Ana Sanjuán⁹  Thomas M. H. Hope⁹  Marion Oberhuber⁹  Justyna O. Ekert⁹  Megan Creasey⁹ 

[1]Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

[2]|Experimental Psychology, University College London, London, United Kingdom

[3]|FMRIB Centre and Jesus College, University of Oxford, Oxford, United Kingdom

[4]|Faculty of Health Sciences, Universidad del Desarrollo, Concepcion, Chile

[5]|Faculty of Medicine, Collaborative Research Centre 1052 “Obesity Mechanisms”, University Leipzig, Leipzig, Germany

[6]|Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom

[7]|Neuropsychology and Functional Imaging Group, Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón de La Plana, Spain

[8]|Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

[9]|Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

关键词: gliomas;    fMRI;    language;    speech perception;    speech production;    right temporal lobe;   

DOI  :  10.3389/fnhum.2022.803163

来源: DOAJ

【 摘 要 】

Using fMRI, we investigated how right temporal lobe gliomas affecting the posterior superior temporal sulcus alter neural processing observed during speech perception and production tasks. Behavioural language testing showed that three pre-operative neurosurgical patients with grade 2, grade 3 or grade 4 tumours had the same pattern of mild language impairment in the domains of object naming and written word comprehension. When matching heard words for semantic relatedness (a speech perception task), these patients showed under-activation in the tumour infiltrated right superior temporal lobe compared to 61 neurotypical participants and 16 patients with tumours that preserved the right postero-superior temporal lobe, with enhanced activation within the (tumour-free) contralateral left superior temporal lobe. In contrast, when correctly naming objects (a speech production task), the patients with right postero-superior temporal lobe tumours showed higher activation than both control groups in the same right postero-superior temporal lobe region that was under-activated during auditory semantic matching. The task dependent pattern of under-activation during the auditory speech task and over-activation during object naming was also observed in eight stroke patients with right hemisphere infarcts that affected the right postero-superior temporal lobe compared to eight stroke patients with right hemisphere infarcts that spared it. These task-specific and site-specific cross-pathology effects highlight the importance of the right temporal lobe for language processing and motivate further study of how right temporal lobe tumours affect language performance and neural reorganisation. These findings may have important implications for surgical management of these patients, as knowledge of the regions showing functional reorganisation may help to avoid their inadvertent damage during neurosurgery.

【 授权许可】

Unknown