Inflammatory Response Following Peripheral Endovascular Treatment Correlates with the Extent of Periprocedural Arterial Injury

Acta Clinica Croatica

卷:57

Vatroslav Šerić¹  Vjekoslav Kopačin²  Gordan Šarić²  Tajana Turk²  Tonći Mišević²  Otmar Rubin²  Vedran Farkaš³  Vedran Ivković³  Damir Kovač³ 

[1] Department of Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;

[2] Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;

[3] Department of Surgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia;

关键词: C-reactive protein;    Fibrinogen;    Stents;    Angiography;    Endovascular procedures;    Angioplasty;   

DOI  :  

来源: DOAJ

【 摘 要 】

The aim was to examine whether the postprocedural change in C-reactive protein (CRP) and fibrinogen levels was associated with the extent of periprocedural arterial injury caused by endovascular treatment (EVT). The study recruited 71 patients undergoing EVT. Eighty-four patients that underwent angiography served as a control group. CRP and fibrinogen were measured at baseline, and at 8, 24 and 48 hours following the procedure. In all experimental group patients, lesion complexity, percutaneous transluminal angioplasty (PTA) treated segment length, balloon inflation time and stented segment length were recorded. There was significant increase in plasma CRP and fibrinogen levels 48 hours following EVT (p<0.001). There was no significant difference in CRP and fibrinogen levels among different TASC groups. CRP levels were significantly higher in stent subgroup compared to PTA subgroup. Significant positive correlation was found between PTA treated segment length and CRP increase between 8 and 24 hours following EVT (r=0.313, p=0.02), balloon inflation time and CRP increase in the aforementioned time frame (r=0.270, p=0.03), as well as between CRP increase at 8 hours and stented segment length (r=0.535, p=0.01). This study showed that the arterial injury caused by EVT reflected on the level of inflammatory biomarkers.

【 授权许可】

Unknown