Shared genetic variance between obesity and white matter integrity in Mexican-americans

Frontiers in Genetics

卷:6

Emma eSprooten¹  Elena A Spieker³  Laura M Rowland³  Anderson M Winkler⁴  Laura eAlmasy⁵  Peter eKochunov⁵  Joanne eCurran⁵  Ravindranath eDuggirala⁵  John eBlangero⁵  Peter T Fox⁷  Rene L Olvera⁷  David eGlahn⁷ 

[1] Institute of Living;

[2] Madigan Army Medical Center;

[3] Maryland Psychiatric Research Center, University of Maryland School of Medicine;

[4] Oxford Centre for Functional MRI of the Brain, University of Oxford;

[5] Texas Biomedical Research Institute;

[6] University of Maryland Baltimore County;

[7] University of Texas Health Science Center at San Antonio;

[8] Yale University;

关键词: Diffusion Tensor Imaging;    Genetics;    Obesity;    Genotype;    white matter;    Fractional Anisotropy (FA);   

DOI  :  10.3389/fgene.2015.00026

来源: DOAJ

【 摘 要 】

Obesity is a chronic metabolic disorder that may also lead to reduced white matter integrity, potentially due to shared genetic risk factors. Genetic correlation analyses were conducted in a large cohort of Mexican American families in San Antonio (N=761, 58% females, ages 18-81y; 41.3±14.5) from the Genetics of Brain Structure and Function Study. Shared genetic variance was calculated between measures of adiposity ((body mass index (BMI; kg/m2) and waist circumference (WC; in)) and whole-brain and regional measurements of cerebral white matter integrity (fractional anisotropy).Whole-brain average and regional fractional anisotropy values for ten major white matter tracts were calculated from high angular resolution diffusion tensor imaging data (DTI; 1.7×1.7×3 mm; 55 directions). Additive genetic factors explained intersubject variance in BMI (heritability, h2=0.58), WC (h2=0.57), and FA (h2=0.49). FA shared significant portions of genetic variance with BMI in the genu (ρG = -0.25), body (ρG = -0.30), and splenium (ρG = -0.26) of the corpus callosum, internal capsule (ρG = -0.29), and thalamic radiation (ρG = -0.31) (all p’s = .043). The strongest evidence of shared variance was between BMI/WC and FA in the superior fronto-occipital fasciculus (ρG = -0.39, p = .020; ρG = -0.39, p = .030), which highlights region-specific variation in neural correlates of obesity. This may suggest that increase in obesity and reduced white matter integrity share common genetic risk factors.

【 授权许可】

Unknown