Impact of the severity of end-stage liver disease in cardiac structure and function

Annals of Hepatology

卷:12

Alberto Queiroz Farias, M.D.¹  Elisangela Belleti¹  Luiz Augusto Carneiro D’Albuquerque¹  Wellington Andraus¹  Flair José Carrilho¹  Vincenzo Pugliese¹  Danusa de Souza Ramos¹  Fernando Bacal²  Odilson Marcos Silvestre²  Meive Furtado³  Jose L. Andrade³ 

[1]Department of Gastroenterology University of Sao Paulo School of Medicine, Brazil

[2]|Heart Institute University of Sao Paulo School of Medicine, Brazil

[3]|Institute of Radiology University of Sao Paulo School of Medicine, Brazil

关键词: Cirrhosis;    Cardiac remodeling;    Liver transplantation;    MELD score;    Cirrhotic cardiomyopathy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background. The impact of end-stage liver disease (ESLD) in cardiac remodeling of patients with cirrhosis is unknown. Our aim was to correlate the severity of ESLD with morphologic and functional heart changes.Material and methods. 184 patients underwent a protocol providing data on the severity of ESLD and undergoing echocardiography to assess the diameters of the left atrium and right ventricle; the systolic and diastolic diameters of the left ventricle, interventricular septum, and posterior wall of the left ventricle; systolic pulmonary artery pressure; ejection fraction; and diastolic function. Severity of ESLD was assessed by the Model for End-Stage Liver Disease (MELD) score.Results. Left-atrial diameter (r = 0.323; IC 95% 0.190-0.455; p < 0.001), left-ventricular diastolic diameter (r = 0.177; IC 95% 0.033–0.320; p = 0.01) and systolic pulmonary artery pressure (r = 0.185; IC 95% 0.036-0.335; p = 0.02) significantly correlated with MELD score. Patients with MELD ≥ 16 had significantly higher left-atrial diameter and systolic pulmonary artery pressure, compared with patients with MELD scores < 16 points.Conclusions. Changes in cardiac structure and function correlate with the severity of ESLD.

【 授权许可】

Unknown