'Equity' and 'Justice' for patients with acute-on chronic liver failure: A call to action

JOURNAL OF HEPATOLOGY

卷:75

Article

Jalan, Rajiv^1,2  Gustot, Thierry^1,3,4,5,6,7  Fernandez, Javier^1,8,9  Bernal, William^1,10 

[1] European Fdn Study Chron Liver Failure EF Clif, Barcelona, Spain

[2] UCL Med Sch, UCL Inst Liver & Digest Hlth, Liver Failure Grp, Royal Free Campus, London, England

[3] CUB Hop Erasme, Liver Transplant Unit, Dept Gastroenterol, Hepatopancreatol, Brussels, Belgium

[4] CUB Hop Erasme, Digest Oncol, Brussels, Belgium

[5] Univ Libre Bruxelles, Lab Expt Gastroenterol, Brussels, Belgium

[6] Ctr Rech Sur Inflammat CRI, Inserm Unite 1149, Paris, France

[7] Univ Paris Diderot, UMR S 1149, Paris, France

[8] Univ Barcelona, Hosp Clin, Liver Unit, IDIBAPS,Liver ICU, Barcelona, Spain

[9] CIBERehd, Barcelona, Spain

[10] Kings Coll Hosp London, Inst Liver Studies, Liver Intens Therapy Unit, Denmark Hill, London SE5 9RS, England

关键词: Acute-on-chronic liver failure;    Liver Transplantation;    MELD score;    EASL-CLIF criteria;    Cirrhosis;   

DOI  :  10.1016/j.jhep.2021.06.017

来源: Elsevier

【 摘 要 】

Acute-on-chronic liver failure (ACLF) occurs in hospitalised patients with cirrhosis and is characterised by multiorgan failures and high rates of short-term mortality. Without liver transplantation (LT), the 28-day mortality rate of patients with ACLF ranges from 18-25% in those with ACLF grade 1 to 68-89% in those with ACLF grade 3. It has become clear that patients with ACLF do not have equitable access to LT because of current allocation policies, which are based on prognostic scores that underestimate their risk of death and a lack of appreciation of the clear evidence of transplant benefit in carefully selected patients (who can have excellent post-LT outcomes). In this expert opinion, we provide evidence supporting the argument that patients with ACLF should be given priority for LT based on prognostic models that define the risk of death for these patients. We also pinpoint risk factors for poor post-LT outcomes, identify unanswered questions and describe the design of a global study, the CHANCE study, which will provide answers to the outstanding issues. We also propose the worldwide adoption of new organ allocation policies for patients with ACLF, as have been initiated in the UK and recommended in Spain. (C) 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free