Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

Polymers

卷:8

Sukumaran Anil¹  Jayachandran Venkatesan²  Min Suk Shim²  Se-Kwon Kim³ 

[1] Department of Preventive Dental Sciences, College of Dentistry, Jazan University, P.O Box 114, Jazan 45142, Saudi Arabia;

[2] Division of Bioengineering, Incheon National University, Incheon 406-772, Korea;

[3] Marine Bioprocess Research Center and Department of Marine-bio Convergence Science, Pukyong National University, Busan 608-737, Korea;

关键词: alginate;    carrageenan;    fucoidan;    drug delivery;   

DOI  :  10.3390/polym8020030

来源: DOAJ

【 摘 要 】

In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for several biological, biomedical, and functional food applications. The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy. Alginate, carrageenan, fucoidan, ulvan, and laminarin are polysaccharides commonly isolated from seaweed. These natural polymers can be converted into nanoparticles (NPs) by different types of methods, such as ionic gelation, emulsion, and polyelectrolyte complexing. Ionic gelation and polyelectrolyte complexing are commonly employed by adding cationic molecules to these anionic polymers to produce NPs of a desired shape, size, and charge. In the present review, we have discussed the preparation of seaweed polysaccharide-based NPs using different types of methods as well as their usage as carriers for the delivery of various therapeutic molecules (e.g., proteins, peptides, anti-cancer drugs, and antibiotics). Seaweed polysaccharide-based NPs exhibit suitable particle size, high drug encapsulation, and sustained drug release with high biocompatibility, thereby demonstrating their high potential for safe and efficient drug delivery.

【 授权许可】

Unknown