Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices

Sensors

卷:19

Jonas Leuermann¹  Robert Halir¹  Íñigo Molina-Fernández¹  Adrián Fernández-Gavela²  Sergio Postigo³  Alejandro Sánchez-Postigo⁴  Antonia Torres-Cubillo⁴  LauraM. Lechuga⁵ 

[1] Bionand Center for Nanomedicine and Biotechnology, Parque Tecnológico de Andalucía, 29590 Málaga, Spain;

[2] Departamento de Física, Universidad de Oviedo, C/Federico García Lorca, 33007 Oviedo, Spain;

[3] Department de Ingeniería Mecánica, Universidad de Málaga, Térmica y de Fluidos, Escuela de Ingenierías Industriales, Campus de Teatinos, 29071 Málaga, Spain;

[4] Department de Ingeniería de Comunicaciones, Universidad de Málaga, ETSI Telecomunicación, Campus de Teatinos, 29071 Málaga, Spain;

[5] Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST and CIBER-BBN Campus UAB, 08193 Barcelona, Spain;

关键词: limit of detection;    coherent detection;    silicon photonics;    interferometer;    biosensors;   

DOI  :  10.3390/s19173671

来源: DOAJ

【 摘 要 】

Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e., the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ∼ ${10}^{-8}\mathrm{RIU}$ with a silicon nitride sensor operating at telecom wavelengths.

【 授权许可】

Unknown