The antinociceptive effects of rubbing Pistacia atlantica oil by formalin test in male labarotory mice

مجله دانشگاه علوم پزشکی بیرجند

卷:24

Rahmatollah Parandin¹  Daryoush Shakibaie²  Namdar Yousofvand³  Shahzad Daroogari⁴ 

[1] Assistant of Animal physiology, Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, Iran.;

[2] Department of Biology, Faculty of Science, Islamic Azad University, branch of Hamrdan, Hamedan, Iran.;

[3] Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran. ;

[4] MSc of Animal physiology , Department of Biology, Islamic Azad University, Hamedan branch, Hamedan, Iran.;

关键词: Baneh;    pain;    male mice;    formalin;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background and Aim: Baneh (Pistacia Atlantica) is a valuable oily fruit that has gained considerable attention because of its pharmaceutical, nutritional and industrial applications. This study aimed to investigate the antinociceptive effect of rubbing baneh oil using formalin test during acute and chronic phases in male laboratory mice.Materials and Methods: This experimental study was conducted on 30 male mice. They were allocated into 5 groups including control (without treatment), rubbing vaseline, morphine (positive control), baneh oil, and baneh oil plus morphine. Before the formalin test, the animals were treated with rubbing baneh oil for six hours. Morphine (10 mg/kg) was injected with a single dose subcutaneously. Pain scores were obtained using formalin test by injecting 0.02 ml of 2.5% formalin into the animals’ right palm.Results: Rubbing baneh oil significantly reduced the pain in acute pain (P <0.01), sub-acute pain (P <0.001), and chronic pain (P <0.001) phases as compared with the control group. On the other hand, baneh oil showed a stronger antinociceptive effect in chronic pain than morphine (P <0.01).Conclusion: This study showed that rubbing Baneh oil has antinociceptive effect where a considerable share of this effect may be attributed to the oil’s compounds. 

【 授权许可】

Unknown