Dissociation of dorsal hippocampal regional activation under the influence of stress in freely behaving rats

Frontiers in Behavioral Neuroscience

卷:5

Vincent eHok¹  Ehsan eChah¹  Shane M O‘Mara¹  Johannes ePassecker¹  Andrea eDella-Chiesa¹ 

[1] Trinity College Dublin;

关键词: Dentate Gyrus;    Hippocampus;    stress;    CA3;    CA1;    Place Cells;   

DOI  :  10.3389/fnbeh.2011.00066

来源: DOAJ

【 摘 要 】

Stress has deleterious effects on brain, body and behaviour in humans and animals alike. The present work investigated how 30-minute acute photic stress exposure impacts on spatial information processing in the main subregions of the dorsal hippocampal formation (CA1, CA3 and Dentate Gyrus), a brain structure prominently implicated in memory and spatial representation. Recordings were performed from spatially tuned hippocampal and dentate gyrus cells in rats while animals foraged in a square arena for food. The stress procedure induced a decrease in firing frequencies in CA1 and CA3 place cells while sparing locational characteristics. In contrast to the CA1-CA3 network, acute stress failed to induce major changes in the DG neuronal population. These data demonstrate a clear dissociation of the effects of stress on the main hippocampal sub-regions. Our findings further support the notion of decreased hippocampal excitability arising from stress in areas CA1 and CA3, but not in dentate gyrus.

【 授权许可】

Unknown