Waning of IgG, Total and Neutralizing Antibodies 6 Months Post-Vaccination with BNT162b2 in Healthcare Workers

Vaccines

卷:9

Sandrine Van Eeckhoudt¹  Grégoire Wieers²  Christine Laurent³  Marc Elsen⁴  Christine Eucher⁴  Vincent Gerin⁵  Jean-Louis Bayart⁵  Tatiana Roy⁵  François Mullier⁶  Mélanie Closset⁶  Julien Favresse⁷  Constant Gillot⁷  Jonathan Douxfils⁷  Jean-Michel Dogné⁷  Clara David⁸ 

[1] Department of Internal Medicine, Clinique St-Luc Bouge, 5004 Bouge, Belgium;

[2] Department of Internal Medicine, Clinique St-Pierre, 1340 Ottignies, Belgium;

[3] Department of Internal Medicine, Université Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium;

[4] Department of Laboratory Medicine, Clinique St-Luc Bouge, 5004 Bouge, Belgium;

[5] Department of Laboratory Medicine, Clinique St-Pierre, 1340 Ottignies, Belgium;

[6] Department of Laboratory Medicine, Université Catholique de Louvain, 5530 Yvoir, Belgium;

[7] Department of Pharmacy, Namur Research Institute for LIfe Sciences, University of Namur, 5000 Namur, Belgium;

[8] Qualiblood s.a., 5000 Namur, Belgium;

关键词: COVID-19;    SARS-CoV-2;    mRNA vaccine;    BNT162b2;    antibody response;    neutralizing antibodies;   

DOI  :  10.3390/vaccines9101092

来源: DOAJ

【 摘 要 】

Data about the long-term duration of antibodies after SARS-CoV-2 vaccination are still scarce and are important to design vaccination strategies. In this study, 231 healthcare professionals received the two-dose regimen of BNT162b2. Of these, 158 were seronegative and 73 were seropositive at baseline. Samples were collected at several time points. The neutralizing antibodies (NAbs) and antibodies against the nucleocapsid and the spike protein of SARS-CoV-2 were measured. At day 180, a significant antibody decline was observed in seronegative (−55.4% with total antibody assay; −89.6% with IgG assay) and seropositive individuals (−74.8% with total antibody assay; −79.4% with IgG assay). The estimated half-life of IgG from the peak humoral response was 21 days (95% CI: 13–65) in seronegative and 53 days (95% CI: 40–79) in seropositive individuals. The estimated half-life of total antibodies was longer and ranged from 68 days (95% CI: 54–90) to 114 days (95% CI: 87–167) in seropositive and seronegative individuals, respectively. The decline of NAbs was more pronounced (−98.6%) and around 45% of the subjects tested were negative at day 180. Whether this decrease correlates with an equivalent drop in the clinical effectiveness against the virus would require appropriate clinical studies.

【 授权许可】

Unknown