Use of Circular RNAs in Diagnosis, Prognosis and Therapeutics of Renal Cell Carcinoma

Frontiers in Cell and Developmental Biology

卷:10

José Luis Górriz²  Rebeca Osca-Verdegal³  José María Martínez Jabaloyas⁴  José Luis García-Giménez⁵  Federico V. Pallardó⁶  Jesús Beltrán-García⁶ 

[1] Center for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Valencia, Spain;

[2] Department of Nephrology, University Clinic Hospital, INCLIVA, University of Valencia, Valencia, Spain;

[3] Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain;

[4] Department of Urology, University Clinic Hospital, INCLIVA, University of Valencia, Valencia, Spain;

[5] EpiDisease S.L. (Spin-Off CIBER-ISCIII), Parc Científic de la Universitat de València, Valencia, Spain;

[6] INCLIVA Biomedical Research Institute, Valencia, Spain;

关键词: RCC (Renal Cell Carcinoma);    circRNAs;    biomarker;    diagnosis;    therapy;    cancer;   

DOI  :  10.3389/fcell.2022.879814

来源: DOAJ

【 摘 要 】

Renal cell carcinoma is the most common type of kidney cancer, representing 90% of kidney cancer diagnoses, and the deadliest urological cancer. While the incidence and mortality rates by renal cell carcinoma are higher in men compared to women, in both sexes the clinical characteristics are the same, and usually unspecific, thereby hindering and delaying the diagnostic process and increasing the metastatic potential. Regarding treatment, surgical resection remains the main therapeutic strategy. However, even after radical nephrectomy, metastasis may still occur in some patients, with most metastatic renal cell carcinomas being resistant to chemotherapy and radiotherapy. Therefore, the identification of new biomarkers to help clinicians in the early detection, and treatment of renal cell carcinoma is essential. In this review, we describe circRNAs related to renal cell carcinoma processes reported to date and propose the use of some in therapeutic strategies for renal cell carcinoma treatment.

【 授权许可】

Unknown