Placental Morphologic Similarities Between ZIKV-Positive and HIV-Positive Pregnant Women

Frontiers in Immunology

卷:12

Lúcia de Noronha¹  Patrícia Zadorosnei Rebutini¹  Seigo Nagashima¹  Mineia Alessandra Scaranello Malaquias¹  Amanda Prokopenko¹  Plínio Cézar Neto¹  Daiane Cristine Martins Ronchi¹  Letícia Arianne Panini do Carmo¹  Emily Scaranello Marini¹  Camila Zanluca²  Claudia Nunes Duarte dos Santos² 

[1] Laboratory of Experimental Pathology, Postgraduate Program of Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil;

[2] Molecular Virology Laboratory, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, Brazil;

关键词: Zika virus;    HIV;    vertical transmission;    placenta;    morphometric analysis;   

DOI  :  10.3389/fimmu.2021.684194

来源: DOAJ

【 摘 要 】

Zika virus (ZIKV) caused global concern due to Brazil's unexpected epidemic, and it was associated with congenital microcephaly and other gestational intercurrences. The study aimed to analyze the placenta morphometric changes of ZIKV-infected pregnant women (ZIKV group; n = 23) compared to placentas of HIV-infected (HIV group; n = 24) and healthy pregnant women (N-control group; n = 22). It also analyzed the relationship between the morphometric results and pathological alterations on conventional microscopy, gestational trimester of infection, and presence of the congenital Zika syndrome (CZS). There was a significant increase in area (p = 0.0172), as well as a higher number of knots (p = 0.0027), sprouts (p < 0.0001), and CD163 +Hofbauer cells (HCs) (p < 0.0001) in the ZIKV group compared to the N-control group, suggesting that villous dysmaturity and HCs hyperplasia could be associated with ZIKV infections. The HIV group had a higher area (p < 0.0001), perimeter (p = 0.0001), sprouts (p < 0.0001), and CD163 + HCs (p < 0.0001) compared to the N-control group, demonstrating that the morphometric abnormalities found in the ZIKV and HIV group are probably similar. However, when ZIKV and HIV groups are compared, it was observed a higher number of sprouts (p = 0.0066) and CD163+ HCs (p < 0.0001) in the first one, suggesting that placental ZIKV congenital changes could be more pronounced.

【 授权许可】

Unknown