Curcumin: A Potent Protectant against Esophageal and Gastric Disorders

International Journal of Molecular Sciences

卷:20

Slawomir Kwiecien¹  Jolanta Majka¹  Agata Ptak-Belowska¹  Marcin Magierowski¹  Tomasz Brzozowski¹  Dagmara Wojcik¹  Katarzyna Magierowska¹  Zbigniew Sliwowski¹ 

[1] Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland;

关键词: curcumin;    reflux esophagitis;    gastroprotection;    gastric ulcer;    Helicobacter pylori;    gastric cancer;   

DOI  :  10.3390/ijms20061477

来源: DOAJ

【 摘 要 】

Turmeric obtained from the rhizomes of Curcuma longa has been used in the prevention and treatment of many diseases since the ancient times. Curcumin is the principal polyphenol isolated from turmeric, which exhibits anti-inflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic activities. The existing evidence indicates that curcumin can exert a wide range of beneficial pleiotropic properties in the gastrointestinal tract, such as protection against reflux esophagitis, Barrett’s esophagus, and gastric mucosal damage induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and necrotizing agents. The role of curcumin as an adjuvant in the treatment of a Helicobacter pylori infection in experimental animals and humans has recently been proposed. The evidence that this turmeric derivative inhibits the invasion and proliferation of gastric cancer cells is encouraging and warrants further experimental and clinical studies with newer formulations to support the inclusion of curcumin in cancer therapy regimens. This review was designed to analyze the existing data from in vitro and in vivo animal and human studies in order to highlight the mechanisms of therapeutic efficacy of curcumin in the protection and ulcer healing of the upper gastrointestinal tract, with a major focus on addressing the protection of the esophagus and stomach by this emerging compound.

【 授权许可】

Unknown