Gastroprotective effects of methanolic extract of kratom leaves on gastric ulcer and reflux esophagitis in rats

Songklanakarin Journal of Science and Technology (SJST)

卷:40

Nisaudah Radenahmad¹  Sujitra Kaewsara²  Somsmorn Chittrakarn³  Wandee Udomuksorn³  Niwat Keawpradub⁴  Pimpimol Phukpattaranont⁵ 

[1] Department of Anatomy, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand;

[2] Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand;

[3] Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand;

[4] Niwat Keawpradub;

[5] Pimpimol Phukpattaranont;

关键词: Mitragyna speciosa (Korth.) Havil.;    kratom;    gastric ulcer;    reflux esophagitis;    mitragynine;   

DOI  :  10.14456/sjst-psu.2018.46

来源: DOAJ

【 摘 要 】

Kratom (Mitragyna speciosa (Korth.) Havil.) is a tropical tree indigenous to Thailand. In traditional medicine, it hasbeen used to treat diarrhea, peptic ulcer, stomach ache or gastric upsets. In this study, the protective effects of a methanolicextract of kratom leaves on peptic ulcer models and reflux esophagitis in rats were studied. A methanolic extract of kratom leavesat a dose of 200 and 400 mg/kg were tested in rats on three induced peptic ulcer models and reflux esophagitis. The peptic ulcermodels were induced by water immersion restraint (WIR) stress, alcohol treatment, and acetylsalicylic treatment. The methanolicextract of mitragynine from kratom leaves and ranitidine decreased the ulcer index significantly in the WIR stress model.Conclusion: Only 400 mg/kg of methanolic extract of kratom leaves and omeprazole decreased the ulcer index in the alcohol andacetylsalicylic acid induced ulcer models. No protective effect of kratom extract was found on the reflux esophagitis model.

【 授权许可】

Unknown