Spatial and Temporal Dynamics and Molecular Evolution of Tula orthohantavirus in German Vole Populations

Viruses

卷:13

Daniela Reil¹  Christian Imholt²  Jens Jacob²  Gerald Heckel³  Anton Labutin³  Nastasja G. Spierling⁴  Stefan Fischer⁴  Sabrina Schmidt⁴  Rainer G. Ulrich⁴  Kathrin Jeske⁴  Ulrike M. Rosenfeld⁴  Stephan Drewes⁴ 

[1] Animal Ecology, Institute of Biochemistry and Biology, University of Potsdam, 14469 Potsdam, Germany;

[2] Institute for Plant Protection in Horticulture and Forests, Julius Kühn-Institute (JKI), 48161 Münster, Germany;

[3] Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland;

[4] Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany;

关键词: rodents;    hantavirus;    monitoring;    population dynamics;    common vole;    field vole;   

DOI  :  10.3390/v13061132

来源: DOAJ

【 摘 要 】

Tula orthohantavirus (TULV) is a rodent-borne hantavirus with broad geographical distribution in Europe. Its major reservoir is the common vole (Microtus arvalis), but TULV has also been detected in closely related vole species. Given the large distributional range and high amplitude population dynamics of common voles, this host–pathogen complex presents an ideal system to study the complex mechanisms of pathogen transmission in a wild rodent reservoir. We investigated the dynamics of TULV prevalence and the subsequent potential effects on the molecular evolution of TULV in common voles of the Central evolutionary lineage. Rodents were trapped for three years in four regions of Germany and samples were analyzed for the presence of TULV-reactive antibodies and TULV RNA with subsequent sequence determination. The results show that individual (sex) and population-level factors (abundance) of hosts were significant predictors of local TULV dynamics. At the large geographic scale, different phylogenetic TULV clades and an overall isolation-by-distance pattern in virus sequences were detected, while at the small scale (<4 km) this depended on the study area. In combination with an overall delayed density dependence, our results highlight that frequent, localized bottleneck events for the common vole and TULV do occur and can be offset by local recolonization dynamics.

【 授权许可】

Unknown